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KMID : 0358419970400030591
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Korean Journal of Obstetrics and Gynecology
1997 Volume.40 No. 3 p.591 ~ p.598
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The Effects of Baseline Ovarian Cysts after GnRH-a Administration on the Clinical Response to Controlled Ovarian Hyperstimulation for Intrauterine Insemination
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김연표
김낙연/김정훈/강병문/장윤석/목정은
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Abstract
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The purpose of this study was to investigate the effects of baseline ovarian cysts after luteal phase gonadotropin-releasing hormone agonist(GnRH-a) administration on the clinical response to controlled ovarian hyperstimulation(COH) for
intrauterine
insemination(IUI). From May 1994 to December 1995, 71 COH cycles using luteal long protocol of GnRH-a for IUI were assessed for the formation of baseline ovarian cysts defined as a mean diameter≥15mm. Outcome data were compared between cycles
with
and
without baseline ovarian cysts. Of 71 COH cycles, baseline cyst≥15mm were noted in 23 cycles(32.4%). Of 23 cyst cycles, baseline cysts≥20mm were noted in 15 cycles and aspirated under transvaginal ultrasonogram guidance. There was no
significant
difference in baseline serum FSH values between cyst cycles and non-cyst cycles. There were also no significant differences in ovarian response as indicated by the number of ampules of ampules of gonadotropin used and duration of gonadotropin
administration in ovarian stimulation, and serum E2 level and number of follicles(≥14mm) on the day of hCG administration between cyst cycles and non-cyst cycles. There was also no significant difference in endometrial thickness measured on the
day of
hCG administration between cyst cycles and non-cyst cycles. Clinical pregnancy rate was somewhat lower in cyst cycles compared with non-cyst cycles(13.0% versus 31.3%), but was not significantly different.
This study suggests that baseline ovarian cysts after luteal phase GnRH-a administration has a potentially harmful effect on the clinical outcome in COH with IUI program.
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KEYWORD
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